Seven hundred and four medical students were selected from a university in Fujian province. The self-designed demographic variables questionnaire, self-control scale, life rhythm scale and subjective well-being scale were used to conduct the questionnaire test. There was a significant positive correlation between self-control and subjective well-being (r=0.511, P < 0.01).There was a significant positive correlation between self-control and life rhythm (r=0.494, P < 0.01).There was a significant positive correlation between the pace of life and SWB (r=0.409, P < 0.01).Self-control level positively predicted subjective well-being (β=0.41, P<0.01), the level of self-control could positively predict the life rhythm (β=0.49, P<0.01).The life rhythm positively predicted subjective well-being (β=-0.22, P<0.01).The rhythm of life plays a partial mediating role in self-control and subjective well-being.The mediating effect was 0.1059, accounting for 20.7% of the total effect.Interests and hobbies played a moderating role in self-control and subjective well-being (β=0.084, t=2.73, P<0.01).