To cultivate biopharmaceutical professionals with "excellent practice and innovative ability", this paper relying on the existing virtual simulation experiment platform, explored teaching practice paths through optimizing teaching materials, integrating ideological and political elements, and scientific research back-feeding teaching, established an immersive online and offline blended teaching mode of Biotechnological Pharmaceutics. This mode focused on cultivating students" ability to learn independently and innovative practice, in order to provide practical experience and reference for other colleges to reform teaching models.