In this paper, the Essential Science Indicators (abbreviated as ESI)database is used to analyze the development of ESI discipline of clinical medicine in Fujian Medical University, and Incites database is used to analyze the research direction, cooperative institutions and fundings of highly cited papers of this discipline from 2010 to 2020.The purpose is to understand the preponderant disciplines and characteristics of highly cited papers in the development of ESI clinical medicine discipline in Fujian Medical University, and to explore the path to enhance the popularity and expand the influence of the discipline.